Yes, within limits. Without the recommended +24VDC power, there is insufficient voltage to operate a typical 2-wire IEPE sensor, but the transmitter can certainly operate off +12VDC supply with 3-wire capacitively-coupled sensors. The communication module also operates at +12VDC. The alarm can be special-ordered with 12VDC relays (instead of typical +24VDC relays). Contact Wilcoxon for more information. Note that no certification currently exists for these modules at low-voltage operation.